الفعالية الصحية لبعض النباتات الطبية على أنسجة ووظائف الكلى لدى الجرذان المصابة بمرض الكبد الدهني غير الكحولي

الفعالية الصحية لبعض النباتات الطبية على أنسجة ووظائف الكلى لدى الجرذان المصابة بمرض الكبد الدهني غير الكحولي

محمد فلاح عايد الفرّاس
ا.د. فريال فاروق حسين
ا.د. محمد جميل محمد
جامعة تكريت / كلية الزراعة / قسم علوم الاغذية

Abstract

Excess weight and obesity are serious problems that occur as a result of an imbalance in energy storage and consumption, which leads to the subsequent accumulation of fat, leading to problems in body functions, especially the liver, which leads to kidney and liver degeneration, resulting in injuries including non-alcoholic fatty liver disease. Males were used in this study. Adult white rats (Rattus norvegicus) of the Sprague dawely breed, whose ages ranged between (2-3) months and their weight (190-200) grams. The experiment was divided into two stages. The first stage was the infection stage and was divided into two groups. The first group was the healthy control group. With five animals, this group was given normal drinking water and food daily for (45) days, and the second group was fed animal fat mixed with the diet at a rate of (30%) of the weight of the diet (high fat food) and is symbolized by (HF) for a period of (45) days and at a rate of (30%) of the weight of the diet (high fat food). 15 animals. At the end of the infection stage, blood biochemical tests were performed for both groups. The study showed a significant increase in the levels of both urea and creatinine compared to the healthy control group (C), while the histological analysis showed clear degeneration in the kidneys of rats that were fed a high-fat diet (HF). During the treatment phase, which lasted (28) days, one of the groups was left to feed on a high-fat diet, and the experimental animals were divided into three groups. The first: They were fed a high-fat diet in addition to Urtica Dioica nettle leaf powder at a rate of (300) mg per day, which is symbolized by ( HF + U.d), the second: fed a high-fat diet in addition to Moringa oleifera leaf powder at a rate of (300) mg per day and symbolized by HF + M.o), the third: fed a high-fat diet in addition to a powder of dandelion leaves Cichorium intybus at a rate of (300) mg per day and symbolized by (HF + M.o). 300 mg per day, symbolized by (HF + C.i). Groups of medicinal plants (nettle, moringa, and dandelion) showed a noticeable improvement in kidney function through a decrease in urea and creatine levels compared to the infected control group (HF). They also showed a noticeable therapeutic improvement in kidney tissue compared to the control group. The infected woman continued to be fed a high-fat diet.

Keywords: high-fat diet, non-alcoholic fatty liver disease, medicinal plants, kidney tissue